Here is the confirmed spoilers for Naruto 576. The Japanese here is kind of tricky, but I think I got most of it. Sasuke notices Itachi, calls out for him to stop, and chases him. Itachi says he can’t stop. There’s an attack by one of them with Susano’o (I’m guessing Sasuke) which is deflected by Susano’o. Meanwhile, targeting Hashirama’s descendants, Edo-Madara locks onto Tsunade as a target.
Sasuke sees Itachi, calls out to him, and chases after him, but Itachi says he can’t stop.
Sasuke attacks with Susano-o, which is repelled by the Itachi’s Susano-o.
Sasuke talks to him like a normal little brother. He has a lot of questions.
Hashirama was the ultimate ninja who could regenerate and perform unparalleled jutsu without performing seals. (not completely sure about this part)
Madara targets Tsunade as she is Hashirama’s descendant.
Tsunade rolls up her sleeves and says “Don’t underestimate the Will of Fire” and the chapter ends.